Current thinking is that incision and drainage of a simple cutaneous abscess is enough. Meaning no antibiotics needed. But can we do better? A recently published article in the NEJM suggests that giving trimethoprim-sulfamethoxazole to patients with skin abscesses can improve cure rate after I and D as well as decrease the likelihood of recurrence.
Mark C. - May 18, 2016 9:32 AM
Can we extrapolate these results to a customary dose of trimethoprim/sulfamethoxazole: 160mg and 800mg, twice daily?
(Treatment Guidelines The Medical Letter , Vol 11, July 2013)
Pierre-Alexandre L. - September 12, 2016 10:59 AM
External validity could be a concern as well.
MRSA prevalence was around 45% in this study.
What if the prevalence was lower around 15-20%, would the difference in clinical cure be as much as 7% like in this study?