Introduction

A 2012 study out of the BMJ looked at patients’ antihypertensive medications and their incident risk for gout. Losartan is the only angiotensin receptor blocker with uricosuric effects, and so it makes sense that it was the only ARB associated with a reduced relative risk of gout flares. For that reason if I have a gout patient that’s on some other antihypertensive, I always tell them to ask their PCP about changing their regimen to include losartan if it’s possible.

Diuretics were associated with a two-fold risk of gout, and I always remember CCU patients developing gout shortly after increasing their diuretic doses. Once neprilysin inhibitors become more widely used, maybe someone can make a combo pill with losartan to help treat these patients in particular.

Choi Hyon K, Soriano Lucia Cea, Zhang Yuqing, Rodríguez Luis A García. Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case-control study BMJ 2012; 344 :d8190

https://www.orthobullets.com/trauma/1058/septic-arthritis--adult

Hi guys, I was reviewing the criteria for septic joint in prosthetics and according to orthobullets WBC >1,100 is considered septic (also varies 1-3 pending on which joint)