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In patients with Cryptococcal Meningitis, adjunctive dexamethasone caused worse clinical outcomes compared with placebo
Steve D. - August 15, 2016 12:47 PM
I appreciate getting to review this paper, but I'm not sure how much you can extrapolate it to the ED. Is one dose of dexamethasone in the ED similar to 6 weeks of treatment like in this trial? Even if the dexamethasone is continued to 1-2 days waiting for culture results, it still likely doesn't have the same risk profile of 6 weeks of steroids. I'm not an expert in the literature on this topic by any means, but I don't think there has been harm shown in the studies of dexamethasone in patients with presumed bacterial meningitis.