Britt Guest, DO reviews the latest COVID-19 updates, discussing candidates for home O2, convalescent plasma, vaccine monitors, and more!
Link to COVID-19 Chapter in CorePendium: https://www.emrap.org/corependium/chapter/rec906m1mD6SRH9np/Novel-Coronavirus-2019-COVID-19
Ian L. - March 17, 2021 4:03 AM
In this week in virology episode 730 in Covid 19 clinical update Dr Daniel Griffin explains the concept of a sequence in the spike protein that does not change if it is to infect humans . -It is called the "conserved " part of the spike protein . -It is a required sequence for the virus to infect human cells . This proposes that if it mutates or is neutralised by antibody it loses infectivity . -An antibody VIR-7831 targets this conserved sequence and it has been used in a trial called COMET-ICE - by gsk -Vir Bio with a interim analyses of 583 patients with claimed 85 % reduction in hospital admission and death compared to patients that received placebo .
But is this an ethical way to test medications ? You can use matched controls who have no way possible of getting this treatment .
Mel H. - March 19, 2021 11:20 AM
Ian - thanks for the heads up - I have not heard that TWIV yet - but I will!
Justin K. - March 21, 2021 12:11 PM
Those are interesting anaphylaxis stats. We have had at least three at our site and we have not given a huge number of vaccinations. This is in Canada and these do get reported through our public health, so I'm wondering if there is a lag in reporting.
Mel H. - March 21, 2021 12:50 PM
Still holding at about 2.5 per million per CDC after 4 million Moderna vaccinations, a little higher for Pfizer.
tom f. - March 26, 2021 5:58 AM
thank you, Brit