I cannot understand why we do not use the Chromogenic Antifactor Xa for the Xa inhibitors and the dilute Thrombin time for Debigitran to help with estimating the number of tablets overdosed and the effect . Described as reliable in Emergency Medical cases Episode88 by Anton Helman's EM nuggets team back in November 2016. BeyerJ et al in Clinical Applications Thromb Hemost 2016 July 423-8 remarks a strong correlation of measured anti factor Xa and apixoban and rivaroxaban concentrations . As the New Direct Oral AntiCoagulants are being now much more prescribed and the problem of Adherence and as yet determined drug interactions emerge these AntiFactor Xa and Dilute Thrombin levels ought be routinely available .
Thank you for your question. Most hospitals, at least in the U.S., do not have these laboratory tests readily available. And, in the institutions that can test for them, the turn around time for reporting results is often too long to be a useful clinical guide in emergency situations.
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Ian L., Dr - July 18, 2018 3:53 PM
I cannot understand why we do not use the Chromogenic Antifactor Xa for the Xa inhibitors and the dilute Thrombin time for Debigitran to help with estimating the number of tablets overdosed and the effect .
Described as reliable in Emergency Medical cases Episode88 by Anton Helman's EM nuggets team back in November 2016.
BeyerJ et al in Clinical Applications Thromb Hemost 2016 July 423-8 remarks a strong correlation of measured anti factor Xa and apixoban and rivaroxaban concentrations .
As the New Direct Oral AntiCoagulants are being now much more prescribed and the problem of Adherence and as yet determined drug interactions emerge these AntiFactor Xa and Dilute Thrombin levels ought be routinely available .
Bryan H. - July 19, 2018 8:07 AM
Thank you for your question. Most hospitals, at least in the U.S., do not have these laboratory tests readily available. And, in the institutions that can test for them, the turn around time for reporting results is often too long to be a useful clinical guide in emergency situations.