This week, Swami and Isaac Bogoch discuss the data behind the medications discussed for COVID treatment and Stuart chats with Sean Nordt specifically about chloroquine and hydroxychloroquine toxicity.
April 6th Breaking News - Medications for COVID - 19 and Chloroquine Toxicity
Anand Swaminathan, MD, Isaac Bogoch, MD, Stuart Swadron, MD, and Sean Nordt, MD
kevin f. - April 8, 2020 1:30 PM
Any possible way you guys could make these audio files into a pdf document?
Matthew N. - April 8, 2020 9:31 PM
I concur.
Sean N. - April 9, 2020 9:51 AM
Hi Kevin and Matthew
We will work on
Be safe
Sean
Robert D. - April 10, 2020 1:13 PM
Can you refer me to the article on the pediatric patient that was referred to?
And.. how much "safer" is hydroxychloroquine (as I understand it, chloroquine in not available in the US, but is around the world)?
Thank you
Bob D.
Sean N. - April 10, 2020 2:02 PM
Hi Robert,
Thank you for the comments
1) The lowest pediatric deaths reported are following 300 mg, ie, one to two tablets depending on strength.
Here is one of the pediatric articles
Kelly JC, Wasserman GS, Bernard WD, et al. Chloroquine poisoning in a child. Ann Emerg Med.1990;19:47-50.
2) Difficult to say how much "safer" hydroxychloroquine is. Deaths several deaths reported in 11-12 gram range where see in 5 gram range in adults following chloroquine ingestions. For me not any difference if evaluating patient.
In acute poisoning or accidental ingestions would be concerned, observe, anticipate same toxicity and treat exactly the same as chloroquine. Call a toxicologist or poison center for guidance. Do not assume hydroxychloroquine safer.
Here is an article on hydroxychloroquine poisoning
Marquardt K, Albertson TE. Treatment of hydroxychloroquine overdose. Am J Emerg Med. 2001;19:420-424.
3) Chloroquine is available in the United States. The brand name Aralen(R) was discontinued but generic is available.
Sean