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Dear EM;RAP:A booster shot for those vaccinated is perhaps going to be offered soon.What is the evidence that this is efficacious?Is there patient oriented outcome data on this?Best,John Bibb, MD
John - excellent question. Mel will be doing some updates on boosters shortly. The summary of the data is that we do see waning efficacy in terms of vaccinated folks getting any infection but sustained efficacy in terms of preventing severe cases/hospitalizations.The data on efficacy of boosters mostly comes out of Israel where boosters have been done and there's an association with declining infections (this is not proof - the data is clearly flawed). The lab data tells us that a booster will result in a higher antibody titer but we don't have strong evidence that that higher titer will create better immunity. However, this does physiologically make sense - having a higher titer is most likely better than having a lower titer.
Dr Swamiwould love to chat with you on a topic that has been troubling me in EM - but would not like it to be in this forum- would you be able to contact me via e mail?
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