Great question! N-acyetylcysteine repletes glutathione, in addition to other actions. This obviates the need for additional glutathione. Early days in acetaminophen poisoning, methionine used to be given then N-acetylcysteine became standard therapy.
Sean
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Lee D. - September 19, 2022 12:13 PM
Any role for addition of glutathione IM in management of Tylenol ingestions?
Sean N. - September 20, 2022 11:16 AM
Hi Lee,
Thanks for the comment!
Great question! N-acyetylcysteine repletes glutathione, in addition to other actions. This obviates the need for additional glutathione. Early days in acetaminophen poisoning, methionine used to be given then N-acetylcysteine became standard therapy.
Sean