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Ron F. -

I was just wondering if you saw the article (referenced below) which looked at Profilnine for reversal of anticoagulation in the setting of ICH. It shows much less reliability and efficacy and potentially more common side effects than previous stuff I've read. I instituted availability of this drug through my job as an ED medical director after this month's EMRAP feature. Since the article, I elected to just let our docs know that this is out there, and I guess the jury's still out on what the right thing is in these cases. Does this article temper the enthusiasm with which Profilnine was promoted during this EM: RAP episode? Any other changes or recommendations for folks in this difficult clinical scenario?

Stroke. 2012 Sep;43(9):2500-2. Epub 2012 Jul 17.

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Episode 117 Full episode audio for MD edition 251:50 min - 105 MB - M4AWritten Summary 188 KB - PDFC3 Summary Hematology Review 216 KB - PDF