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Kevin P. - November 3, 2017 3:10 PM
Could someone please link to studies supporting the use of furosemide without worsening kidney function?
Bryan H. - November 3, 2017 3:23 PM
Residual kidney function was prospectively evaluated among 61 peritoneal dialysis patients randomly assigned to either furosemide (250 mg/day) or no furosemide (https://www.ncbi.nlm.nih.gov/pubmed/11231370). At 6 and 12 months, urine volume was significantly higher in the group receiving the diuretic, but the clearance of both creatinine and urea had declined at a constant rate in both groups. Another study found patients with residual renal function on diuretic therapy had almost twice the odds of retaining RRF after 1 year in the study versus patients not on diuretic therapy. (https://www.ncbi.nlm.nih.gov/pubmed/17336704).