In the acute CHF article commentary, the bolus dose used was a TOTAL up to 2 MG. The drip dose used was up to a max dose of 35 MCG/min. Does it not seem to be aggressive bolus doses but small drip doses? I thought we titrate the drip up to 100-150mcg/min.
Agreeed, it seems like a bit of a paper tiger to compare such high dose boluses and comparatively low dose drips. Since it retrospective, it was pretty much whatever the treating doc wanted. Perhaps at a higher drip rate there wouldn't have been such a difference in the primary outcome.
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Skins, MD - December 1, 2016 4:05 PM
In the acute CHF article commentary, the bolus dose used was a TOTAL up to 2 MG. The drip dose used was up to a max dose of 35 MCG/min. Does it not seem to be aggressive bolus doses but small drip doses? I thought we titrate the drip up to 100-150mcg/min.
Rob O - December 2, 2016 9:50 AM
Agreeed, it seems like a bit of a paper tiger to compare such high dose boluses and comparatively low dose drips. Since it retrospective, it was pretty much whatever the treating doc wanted. Perhaps at a higher drip rate there wouldn't have been such a difference in the primary outcome.