What's the Deal with DNA Vaccines? | Brianne Barker, PhD

Mel talks with Brianne Barker PhD about DNA vaccines, single dose efficacy of mRNA vaccines, and 1/2 dose vaccine data.

Ian L., Dr -

Many are asking about safety of the vaccine in pregnancy .
What do virologists think of this ?
Would pre and post exposure monoclonal antibody be safer ?

Stephen J. -

These updates are really wonderful. When Sorrento Pharmaceuticals came out saying they had a DNA vaccine coming online, I thought that doesn't sound like something I want. This helped clarify things!

Stephanie K. -

This was such a great update, thank you so much for the information. I just thought it may be of interest regarding the discussion on potential single dose of mRNA vaccines, that we had 2 nurses in our small hospital come down with COVID (with symptoms and positive tests), after getting their first dose of the Pfizer vaccine. Both were vaccinated on 12/17/20 and one woke up with symptoms 12/27/20 and the other on 1/2/21. Thankfully, both are doing fine and back to work off quarantine now, but certainly would make me hesitant to only receive a single dose. In that same vein, I was trying to find information on when would be best for them to get their second dose of the vaccine? I thought maybe wait a month? Any thoughts or information would be much appreciated. Cheers.

Mel H. -

From the CDC Guidelines: Vaccination of persons with known current SARS-CoV-2 infection should be deferred until the person has recovered from the acute illness (if the person had symptoms) and criteria have been met for them to discontinue isolation. This recommendation applies to persons who develop SARS-CoV-2 infection before receiving any vaccine doses as well as those who develop SARS-CoV-2 infection after the first dose but before receipt of the second dose. While there is otherwise no recommended minimum interval between infection and vaccination, current evidence suggests that reinfection is uncommon in the 90 days after initial infection. Thus, persons with documented acute SARS-CoV-2 infection in the preceding 90 days may delay vaccination until near the end of this period, if desired.

Stephanie K. -

Great, thank you!

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